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6 However, GLP-1 receptor agonists and gut-derived GLP-1 do not cross the bloodbrain barrier and cannot access GLP-1 receptors in the brain parenchyma, which can only be accessed by brain (pre-proglucagon neuron)-derived GLP-1

9 Inhibition of AMPK mitigates the effect of exendin-4 on APP processing in vivo
If you can't do 2 minutes, 1 minute, whatever you can do so you don't have post-exertional malaise

Tirzepatide is a dual agonist, binding both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

Conversion charts are not one-size-fits-all
