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Regulatory environment & payer interest: Because obesity and type 2 diabetes are recognized large unmet markets, there is likely strong interest from regulators and payers in therapies that are effective, more convenient, possibly less expensive

A few have developed orthostatic hypotension, which causes a sudden drop in blood pressure when standing

In observational studies, naltrexone alone has been shown to have the ability to antagonize dopamine secretion and reduce food intake and binge eating behavior

In addition to enhanced ubiquitination, proteasome dysfunction contributes to sarcopenia