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These gut-derived hormones are released in response to food intake, and have the following effects: Promoting insulin release (insulin lowers blood sugar) Blocking glucagon release (glucagon raises blood sugar) Delaying gastric emptying to prevent post-meal highs Promoting a feeling of fullness so you eat less at any given meal Previously approved incretin-based therapies mimic only the GLP-1 hormone

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Your healthcare provider may recommend other medication combinations instead

To help ease some of the side effects from GLP-1s, doctors typically start at a lower dose and increase gradually to help the body adjust to the medicine as its increased

Holz Iv GG, Kiihtreiber WM, Habener JF