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In addition, a clinical DDI study was conducted to investigate the inhibitory effect of the absorption enhancer for oral semaglutide (SNAC) on BCRP, OAT1/3, and OATP1B1 based on in vitro data.140 However, the administration of SNAC alone did not alter the plasma concentrations of furosemide (an OAT1 and OAT3 substrate) or rosuvastatin (a BCRP and OATP1B1 substrate)

The medication should be discontinued at least 2 months before planned pregnancy due to long half-life

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Alternatively, surgeries such as RYGB were also thought to be malabsorptive in that the intestinal rearrangement would limit macronutrient absorption and calories would be lost during elimination (8, 9)