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Raza FA, Altaf R, Bashir T, et al

These initiatives remain early stage and subject to substantial scientific, clinical and regulatory uncertainty

Sitagliptin Add-on Therapy in Patients with Type 2 Diabetes Inadequately Controlled on Metformin Alone In a 24-week placebo-controlled trial of sitagliptin 100 mg administered once daily added to a twice daily metformin regimen, there were no adverse reactions reported regardless of investigator assessment of causality in 5% of patients and more commonly than in patients given placebo
Therefore, FAS inhibition reduces hepatic steatosis and de novo lipogenesis [44]
