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Unlike our observations in tirzepatide-treated DIO mice, tirzepatide treatment in lean mice skewed CD8+ TILs towards a less differentiated phenotype, as evidenced by increased CD62L and SlamF6 and reduced CD44, T-bet, TOX, and CD27 ( Figure 3K-L )

We assert that incretin drug research would benefit from popPK studies that include more metabolically diverse populations

MOTS-c and inflammation By analyzing the changes in inflammatory cytokines in mices serum, the analgesic effect of MOTS-c licking time was evaluated, as well as its anti-inflammatory effects (8)