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In the 1960s, it was shown that orally administered glucose induces a much larger insulin response than that induced by intravenously administered glucose, despite the similar resulting plasma glucose levels: the incretin effect 18

Appetite suppression remains strong and consistent

Dysregulated insulin, cortisol, thyroid hormones, and leptin can also make it difficult to lose visceral fat

GIPR Antagonists It has been reported that the insulinotropic effect of GIP is severely compromised in patients with obesity-diabetes [115], although the effect is partially restored after optimization of glucose regulation through intensified insulin therapy [116]

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