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Comparison of GLP-/GIP dual agonists and GLP-1 GLP-1 and GIP, both major members of the incretin family, play a physiological role by binding and activating corresponding receptors to promote postprandial insulin secretion [125]

This triple action is the main difference between retatrutide and many existing weight loss medicines

Clinical pharmacology biopharmaceutics review: Ozempic
Glucagon-Like Peptide 1 Modulates Calcium Responses to Glutamate and Membrane Depolarization in Hippocampal Neurons

A Review on Semaglutide: An Oral Glucagon-Like Peptide 1 Receptor Agonist in Management of Type 2 Diabetes Mellitus