united therapeutics glp-1 receptor agonist “Weighing In” on Agonists for People With HIV GLP-1 receptor agonists | How

In this manuscript we report: 1) for the first time our findings on the (3 + 2) methodology, 2) expanded substrate scope for the (4 + 3) annulation, 3) the identification of one of these compounds, JWU-A021, as a potent GLP-1 secretagogue, and 4) experimental evidence indicating that JWU-A021 likely operates in the intestinal L-cells by elevating the intracellular [Ca 2+ ] by means of activating the Transient Receptor Potential Ankyrin 1 channel (TRPA1) 4

[DOI] [PubMed] [Google Scholar] 103.Neal B., Perkovic V., Matthews D.R

4,5 TABLE 1 provides a summary of key characteristics of currently available injectable GLP-1 receptor agonists

(2023) 46:S128S39

Park S, Dong X, Fisher TL, et al