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In patients with type 2 diabetes being treated with diet and exercise, 1.0 mg of subcutaneous semaglutide (Ozempic) reduced body weight by an average of 4.5 kg (9.9 lbs) compared to 3.7 kg (8.1 lbs) in patients with 14 mg of oral semaglutide (Rybelsus). While both medicines are very effective at losing weight, the average weight loss with Ozempic is greater than with Rybelsus

Why GLP-1 Medications Cause Burping and Gas GLP-1 drugs work by mimicking a natural hormone that signals fullness and slows digestion

Why Side Effects Occur Sooner If you take your dose early, the peak concentration of the drug will hit your system sooner than your body expects

This can lead to: Intense nausea or vomiting Severe bloating and gas Abdominal cramping Diarrhea or constipation Blood Sugar Fluctuations For individuals who are also managing blood sugar levels, injecting early can cause a more pronounced drop in glucose

The European Medicines Agency conducted a comprehensive review in 2013 and concluded that available data did not confirm increased pancreatic cancer or pancreatitis risk, but recommended continued monitoring