glp 1 agonists moa Glucagon-like peptide-1 receptor: mechanisms and advances in therapy GLP1 Receptor Agonists—Effects beyond Obesity

It also reduces appetite by having a negative impact on GE and by enabling insulin release from the pancreas, acting in tandem with GLP-1 [26]

Increasing evidence has demonstrated that GLP-1 analogues can cross the blood-brain barrier, protect dopaminergic neurons in the substantia nigra, and rescue motor activity and cognitive functions in PD animal models (5961)

Pharmacological Profile of Once-Weekly Injectable Semaglutide for Chronic Weight Management. Expert Review of Clinical Pharmacology

PMID: 22182839

Further studies are warranted to assess the exact site of absorption and the optimal dosage for the desired action with tolerable adverse effects