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JAMA 321(1):6979 Sato T, Aizawa Y, Yuasa S, Kishi S, Fuse K, Fujita S, Ikeda Y, Kitazawa H, Takahashi M, Sato M, Okabe M (2018) The effect of dapagliflozin treatment on epicardial adipose tissue volume
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The Role of GLP-1 Agonists in Esthetic Medicine: Exploring the Impact of Semaglutide on Body Contouring and Skin Health

GIP Receptor Antagonism Reverses Obesity, Insulin Resistance, and Associated Metabolic Disturbances Induced in Mice by Prolonged Consumption of High-Fat Diet
This occurs because the appetite-suppressing effects and delayed gastric emptying cease, leading to increased hunger and food intake returning to pre-treatment levels

Current theories regarding leptin resistance in obesity suggest it may arise due to pathologic changes in the blood-brain barrier, potentially preventing leptin from entering the central nervous system
