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[4] A major double-blind study (17,604 participants) showed semaglutide (Wegovy) reduces major adverse cardiovascular events by 20% in adults with overweight/obesity and established cardiovascular disease, but without diabetes

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Exendin-4 Ameliorates Lipotoxicity-induced Glomerular Endothelial Cell Injury by Improving ABC Transporter A1-mediated Cholesterol Efflux in Diabetic apoE Knockout Mice

VA users with type 2 diabetes (T2D) who used sulfonylureas or GLP-1RAs between 2017 and 2023 were identified, with follow-up extending until the outcome occurred, 3 years after treatment initiation, or 31 December 2024, whichever came first

In contrast, the SMR method has a narrower 95% CI, potentially suggesting higher accuracy although its OR value approaches 1