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In addition to impaired EEC signaling and gut peptide release, GF models have impaired ENS activation compared with conventionalized and specific-pathogen-free models 245,246
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This is why a slow titration schedule, spending at least four weeks at each dose level, is recommended
Abdul-Ghani M, Norton L, DeFronzo RA
Goebel, M., Stengel, A., Wang, L
