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This seemingly paradoxical outcome was possible because postabsorptive energy expenditure was dramatically increased with brain GLP-1 blockade, as indicated by increased insulin-sensitive glucose utilization in glycolytic muscle and white adipose tissue, as well as increased locomotor activity and cold-induced thermogenesis (16)

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1 Advances in pharmacological management have introduced glucagonlike peptide1 receptor agonists (GLP1 RAs) as effective agents for glycemic control and weight reduction

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