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Whether adding GLP-1 to metformin provides better beta cell survival and delays disease progression remains to be validated.
PlexusDx explains the interaction risks, safe alternatives, and how to manage pain during GLP-1 therapy

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Semaglutide weight loss typically becomes noticeable within the first month, with the strongest results appearing between weeks 8 and 16 of treatment

No drug interactions with common antidepressants, and recent FDA, EMA, and MHRA reviews confirm safety.
