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#Semaglutide improves heart failure-related symptoms and physical function and results in greater weight loss compared with placebo in patients with #HFpEF and #obesity #ESCCongress STEP-HFpEF trial

GLP-1 based therapies led to statistically significant reductions in the serum levels of brain natriuretic peptide (40.16 [51.50, 28.81]

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Cardiovascular Effects Dose-dependent increases in heart rate were observed with retatrutide: Heart rate increases peaked at approximately 24 weeks Gradually declined thereafter while remaining elevated above baseline This pattern is similar to that observed with other GLP-1 receptor agonists[4] The clinical significance of these heart rate changes requires further evaluation in larger and longer-term studies
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