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Injectable GLP-1s may be more suitable for: Patients aiming for the maximum possible reduction in body weight, those with co-existing conditions like heart disease or chronic kidney disease (due to specific FDA approvals for Ozempic), or those who prefer a simple weekly medication schedule

The risks associated with older drugs like fen-phen are not present with todays treatments

Those with a history of arrhythmias, uncontrolled hypertension, coronary artery disease, or previous cardiac events should approach this combination with extreme caution

George Ball, an associate professor of operations and decision technologies at Indiana Universitys Kelley School of Business in Bloomington, said the FDAs allowing compounders to step in created a self-induced conundrum for the agency

In September 2025, researchers at UCLA published a study in ACR Open Rheumatology (Kellner and colleagues)