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The published research that established tirzepatide's efficacy examined doses of 5 mg to 15 mg weekly, with the 2.5 mg dose studied only as a short-term titration step

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J Pediatr Surg 39:448452 discussion 448-52 Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP

Within the brain, GLP-1R is primarily expressed in neurons, and activation of neuronal GLP-1R signaling has been linked to systemic antiinflammatory effects (22)