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Comparing tirzepatide and semaglutide Mechanism of action Semaglutide is a long-acting GLP-1 receptor agonist that stimulates glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying and induces satiety

In women with obesity, excess adipose tissue increases peripheral conversion of androgens to estrogens through aromatase activity, potentially disrupting normal menstrual cyclicity

Compounded GLP-1 medications are not FDA-approved

Plan on check-ins at about 4, 8, and 12 weeks to track weight, waist, habits, and any side effects

Finally, adjusted indirect comparisons may not account for residual confounding because of unobserved differences between trials and, therefore, these findings cannot replace a direct headtohead trial, and conducting a trial to compare tirzepatide and semaglutide 2 mg would validate these findings
