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Marc Jean-Gilles, DO, FACOG.

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GLP-1 receptor agonists such as semaglutide are primarily designed for blood sugar control and weight management, but emerging research suggests indirect effects on stress hormone pathways

Our analysis identified a calcium signaling bottleneck as the central explanation for the EVOKE biomarker-clinical disconnect why semaglutide reduced CSF tau and neuroinflammation markers by ~10% yet failed to slow cognitive decline on CDR-SB