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Currently, several long-acting dual GLP-1R/GCGR agonists are in various stages of clinical development

The 2 mg injectable dose is orders of magnitude lower than oral therapeutic doses, though subcutaneous bioavailability is higher than oral bioavailability

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Some medications, like semaglutide and tirzepatide, are approved for both type 2 diabetes management and weight loss

In new data from the ATTAIN-2 trial presented at ObesityWeek, researchers revealed the oral GLP-1 also induced similar benefits for adults with overweight or obesity and type 2 diabetes