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Limited head-to-head studies compare established glucagon-like peptide-1 receptor agonists (GLP-1 RAs), dipeptidyl peptidase-4 inhibitors (DPP-4is), and sodium-glucose co-transporter-2 inhibitors (SGLT-2is) to insulin in the management of uncontrolled type 2 diabetes mellitus (T2DM)

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A 2024 RCT found semaglutide reduced hip bone density by 2.6% and lumbar spine by 2.1% in one year

Use of glucagon-like peptide 1 agonists for weight loss compared with bupropion-naltrexone was associated with an increased risk for pancreatitis, gastroparesis and bowel obstruction but not biliary disease, researchers reported in JAMA

DPP-4i HR range from 0.78 [0.601.01] to 0.93 [0.831.04]) Lets conclude once and forever that there is no increased risk of thyroid tumors at all with GLP-1 RAs