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Most incretin-based therapies drive impressive fat loss, but at a cost: significant lean mass depletion worse metabolic health higher long-term risk, especially in Diabetes This graphic highlights a two-pronged approach: Semaglutide reduces appetite & fat mass Bimagrumab blocks ActRIIA/B signalling, preventing muscle atrophy Clinical data (BELIEVE trial) shows that combining the two: enhances fat loss preserves or increases lean mass improves overall body composition, not just the number on the scale In a season where weight gain is almost guaranteed, the future of obesity treatment isnt eat less and lose everything. Its lose fat while building muscle

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95% CI 0.35, 3.14)