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The peptide's design achieves this through careful ratio optimization of glucagon-to-GLP-1 receptor activity, ensuring that the glucose-lowering effect of GLP-1 agonism predominates over glucagon's glycogenolytic action while preserving glucagon's catabolic benefits on fat metabolism and energy expenditure

doi: 10.1093/asj/sjad240 [DOI] [PubMed] [Google Scholar] 28

Meanwhile, companies are charting their year ahead, highlighting key business and drug pipeline updates

Indeed, CAPTURE, a multinational, crosssectional study [83] including 9823 adults with T2DM, found that less than 25% of T2DM patients are prescribed a glucose-lowering agent with proven cardiovascular benefit [83]

Both are semaglutide, so switching is straightforward with prescriber approval