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Regarding lipotoxicity, a study in kidneys of mice fed a high-fat diet (55) revealed that the GLP-1 receptor agonist dulaglutide changed the lipid content of the organ, including reductions in diacylglycerols, phosphatidic acids, phosphatidylglycerols, and triglycerides

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However, despite a trend towards lower ACTA2 expression in cells treated with the dual agonist, none of these compounds showed capacity to reduce TGF-induced levels of fibrotic markers (Fig

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