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Palmer SC, Tendal B, Mustafa RA et al (2021) Sodiumglucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials

Retatrutide is not yet FDA-approved, so direct comparison in real-world use is not yet possible

In a study analyzing the risk of hypoglycemia after glucose-lowering treatment utilizing the Japanese Adverse Drug Event Report (JADER) database, lixisenatide also showed higher ROR and IC values than the other two GLP-1RAs, exenatide and liraglutide (35)

The potential role of Zn 2+ has found increasing interest due to the fact that genome-wide association studies (GWAS) have revealed that rare variants of a Zn 2+ transporter gene are associated with improved glucose homeostasis and protection from T2DM (65)

Capsules (non-enteric coated), containing each of the GLP-1 analogues combined with the Axcess delivery formulation (66 mg chenodeoxycholic acid and 33 mg of propyl gallate) were introduced into the intestine after fasting overnight, and blood samples were taken via the saphenous vein for 6 hours thereafter, prior to feeding