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While experimental data from the newer patent suggests improved GLP-1 receptor agonist activity compared to Orforglipron, the extent of the improvement might not be sufficient to establish inventive step for these compounds
Journal of Alzheimers Disease , 101 (s1), S357-S370
The downstream pathways are mainly the PI3K and MAPK pathways
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Additionally, all participants in the highest-dose group achieved at least 5% weight loss, with 26% of participants losing 30% or more of their baseline weight [R]
