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A 2020 study in the European Journal of Pharmacology found that tolerance does develop toward GLP-1 receptor agonist glucose-lowering effects in mice

1 The side effects were consistent with what you'd expect from GLP-1-class drugs: nausea, diarrhea, constipation, and decreased appetite were the most common

Pharmacology & Therapeutics, 245, 108377

Sitting on the toilet 15-20 minutes after meals leverages your body's natural post-meal gastric reflex
