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A safer pace is: Plateaus often happen around 812 weeks

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" "For patients diagnosed with diabetes mellitus on a very low energy/liver reduction diet for the purposes of surgery, sodium-glucose cotransporter-2 inhibitors should be stopped at commencement of the diet, and adjust diabetes mellitus treatment as necessary." "Written sick-day rules should be provided to patients at pre-operative assessment and at discharge." 3.5 Comparison with Other Guidelines: 3.5.1 American Heart Association (AHA) Guidelines [4] : "In patients scheduled for NCS, SGLT2i should be discontinued 3 to 4 days* days before surgery to reduce the risk of perioperative metabolic acidosis (COR I/LOE C-LD) *Canagliflozin, dapagliflozin, and empagliflozin should be stopped 3 days and ertugliflozin 4 days before scheduled surgery." 3.5.2 European Society of Cardiology (ESC) Guidelines [5] : "It should be considered to interrupt SGLT-2 inhibitor therapy for at least 3 days before intermediate- and high-risk NCS." (Class IIa/Level C) 3.5.3 ESAIC Guidelines [3] : "R12.8: SGLT2 inhibitors (SGLT2i) drugs should be withheld for 3 to 4 days before elective procedures to reduce the risk of euglycemic diabetic ketoacidosis

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Researchers concluded that those taking tirzepatide were significantly more likely to achieve weight loss, but added that more studies are needed to better understand the full range of benefits and effects both drugs have on patients