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In the absence of cAMP, the regulatory region of Epac2 is responsible for the autoinhibition of the catalytic function

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These data support that the presence of an amino acid residue with a branched aliphatic side chain, or a methionine, at position 585 of albumin is required for optimal FcRn binding

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Furthermore, it slightly reduced the increase of glucose transporter types 1 and 4 (GLUT1/4) during adipogenesis and led to a rise of GLP-1 mRNA, though protein levels remained unchanged