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Approved in 2022 for diabetes (brand Mounjaro), tirzepatide produced extraordinary results in weight loss up to ~22% in obese participants at the highest dose in a phase 3 trial ( [137] )

By contrast, mGIPR-Ab/P1-treated Gipr Syn/ mice only lost 12% of their body weight despite preservation of intact GLP-1R signalling (Fig
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doi: 10.1186/s12933-018-0738-4
For instance, our projected eligible population is larger than the CBOs and remains higher in future estimates (total of 30 million vs 12.5 million in 2026 and decreased to 11.9 million in 2034)
