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Forty percent suffered leg cramps more than three times a week, with 21% describing their symptoms as very distressing. In fact, up to 20% of people who have leg cramps find their daily symptoms severe enough to seek medical attention

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Similarly, expression of cell signature genes, transthyretin ( TTR ), vitamin Dbinding protein ( GC ), crystallin A2 ( CRYBA2 ), aldehyde dehydrogenase 1 family member A1 ( ALDH1A1 ), and transmembrane 4 L 6 family member 4 ( TM4SF4 ), was highest in the -3 and 4 subclusters (Figure 3D)

have overactive thyroid, glaucoma (increased pressure in the eyes), agitation or a history of drug abuse

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