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Conclusions In this cohort study, the GLP-1 receptor agonist-SGLT-2 inhibitor combination was associated with a lower risk of major adverse cardiovascular events and serious renal events compared with either drug class alone

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Exenatide treatment ameliorates these morphological alterations and inhibits the mitochondrial apoptotic pathway by suppressing cytochrome c release and favorably modulating the expression of pro-apoptotic (Bax, caspase-3) and anti-apoptotic (Bcl-2) proteins, thereby protecting RGC-5 cells from hyperglycemic injury [43]

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We therefore suggest future studies to more thoroughly report maternal and treatment characteristics including trimester of exposure

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It is well-established that elevated peripheral insulin levels can modify insulin receptor expression and affect insulin sensitivity in skeletal muscle and adipose tissue (35)

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All four indicators should be present before increasing

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