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Table 2 Key published studies demonstrating the safety and tolerability of DPP-4 inhibitors

Knop Time courses and incremental AUCs (iAUC) of postprandial plasma concentrations of glucagon-like peptide 1 (GLP-1) and glucagon.

A vial that might safely sit in the fridge for 90 days could become compromised much sooner at room temperature, not because the semaglutide degrades, but because the bacteriostatic preservative cannot keep up with bacterial proliferation in warmer conditions

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Across the 40 weeks of treatment, weight loss ranged from 6.2 to 8.8 kg (greater than what was seen in early Phase 2 semaglutide trials) (NCT03954834)