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An updated meta-analysis of nine randomised controlled trials (RCTs), including 8,920 patients with HF and T2D, reported a 13% reduction in major adverse cardiovascular events in the GLP-1 RA compared with placebo arm

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7.3 A Phase III Study Testing Exendin-4 in PD Following on from this successful study, the same team conducted a phase III study

Together these 1987 reports converted GLP-1 from a sequence inferred from a gene into a characterized endocrine hormone