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An estimated 14.9 million adults in the United States are affected, and prevalence continues to rise alongside obesity and type 2 diabetes
research funding: Kodiak, Genentech, Regeneron
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Cardiovascular outcome trials (SUSTAIN-6) revealed a 26% reduction in major adverse cardiac events, suggesting benefits beyond metabolic control
The chemosensor believed to be the main receptor of bile acids is TGR5, also known as GPR131 or GPBAR1 among other names
