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First, retrospective observational studies using patient EHRs can suffer from inherent limitations including over-/under-/mis-diagnosis, unmeasured or uncontrolled confounders and biases

Johnstone M, Buddhdev P, Peter M, Diggory R

Or Jarrod, who shed 55 kg in 12 months an impressive 35% of his 155 kg starting weight

Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution

While individual results differ based on factors like diet adherence and physical activity, most patients notice changes in appetite within the first week and start seeing real weight loss by the fourth week