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Coskun T, MOYERS JS, ROELL WC, et al (2021) 679-P: the novel GIP, GLP-1, and glucagon triple receptor agonist LY3437943 exhibits robust efficacy in preclinical models of obesity and diabetes

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Serial blood samples were collected for PK analysis at pre-specified intervals up to 672 h after the final dose (pre-dose, 4, 6, 12, 24, 36, 48, 72, 120, 168, 336, and end-of-study at 672 h)

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Second, polyphenols can directly interact with metabolic signalling pathways including AMPK (a cellular energy sensor) and NF-kB (a master inflammatory regulator)