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In clinical trials, patients on Topamax showed significant improvements compared to those on a placebo, with a marked decrease in the number of binges

Ozempic lived up to the drug companys expectations and blew Trulicity out of the water

Phase 2 Trial: The Numbers The pivotal retatrutide Phase 2 trial (NEJM, June 2023, Jastreboff et al., NCT04881760) is the most-cited single source for retatrutide research statistics through to the readout of the Phase 3 TRIUMPH programme

Tirzepatide (Zepbound) has shown the highest average weight loss in trials, at up to 21%, compared to about 14 to 18% for semaglutide (depending on form and dose) and 11% for oral orforglipron

Blevins JE, Ho JM