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DPP4 deficiency in rats A major part of the literature is dealing rather with DPP4-KO in rats than in mice

MECHANISM OF ACTION Glucagon-like peptide 1 receptor agonists mimic the action of naturally occurring GLP-1 agonist, a hormone secreted by the lower gastrointestinal (GI) tract in response to ingestion of food

Bretault M, Carette C, Zaharia R, Vychnevskaia K, Bouillot JL, Czernichow S, Raffin-Sanson ML

If you are considering combining these medications, this is absolutely a conversation to have with your prescribing physician

For the subgroup analysis, the studies were classified based on whether the patients from the control group had received metformin or placebo