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BMJ 2023;382:p2019.Article 72
The study design was an active-comparator new user design,11 with DPP4 inhibitors as the comparator
While these findings suggest a role for GLP-1 signaling in central reward pathways, a critical question remains regarding the extent to which pharmacological effects observed in the brain reflect direct engagement of central GLP-1 receptors versus indirect modulation through peripheral mechanisms
Uchiyama S, Sada Y, Mihara S, Sasaki Y, Sone M, Tanaka Y
Each category evaluates a different dimension of the two peptides
