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GLP-1R desensitisation kinetics and -arrestin recruitment differ markedly between nave and dose-adapted states, so dose-jumping confounds pharmacodynamic readouts [5][6]

All drugs targeting GLP-1 receptors currently have the potential risk for pancreatitis, gallbladder disease, and gastrointestinal intolerance

Eligibility requires specific BMI thresholds (30 kg/m or 27 kg/m with comorbidities) and previous weight loss attempts, not food noise alone