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TRIUMPH (obesity-focused, 4 core registrational trials) has TRIUMPH-1 and TRIUMPH-4 complete, with TRIUMPH-2 (obesity+diabetes) and TRIUMPH-3 (obesity+cardiovascular disease) expected later in 2026

The results are not only significant but also sustainable over time

Cumulative food intake ( c , e ) was assessed per cage in single-or double-house mice

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Understanding this mechanism is essential for both clinicians and patients, as it underscores that constipation is a predictable pharmacologic effect rather than an idiosyncratic reaction