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The sustained release of pro-inflammatory cytokines, increase in the levels of reactive oxygen species and related oxidative stress, the dysregulated cellular proliferation, as well as the intraductal pressure due to stenosis of the pancreatic duct(s) characteristic of chronic pancreatitis increases the risk of possible malignant transformation of the pancreas leading to pancreatic cancer (by approximately 26-fold), a diagnosis with a significantly high risk of an unfavorable prognosis [66,70,71,72,73]
