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Evidence-based comparison of liraglutide (Saxenda/Victoza) and semaglutide (Wegovy/Ozempic), including the STEP 8 head-to-head trial, SCALE vs STEP data, and cardiovascular outcomes from LEADER and SELECT.

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We find that semaglutide prevents brain infiltration of neutrophils, excessive cytokine release, and suppresses neuroinflammation-associated transcriptional signatures specifically in microglia, endothelial cells, and a subset of pericytes