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A Narrative review of diabetic kidney disease: previous and current evidence-based therapeutic approaches

The data on newer agents are even more striking, with tirzepatide demonstrating significantly greater weight loss (20.2%) than semaglutide (13.7%) in head-to-head trials

Medications can help by suppressing appetite, increasing feelings of fullness, or reducing the absorption of fat, which can lead to significant weight loss when combined with lifestyle changes

This fundamental difference in mechanism leads to substantially different outcomes

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