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Individual covariates identified as statistically significant were included in a full model, and each covariate was tested for statistical significance when removed (a model objective function value increase of 10.828 points for a 2 distribution

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Characteristics of the included studies A total of 1789 articles were retrieved from PubMed and Embase databases

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Key variants in the GLP1R gene (rs6923761), GIPR gene (rs1800437), and MC4R gene (rs17782313) predict differential treatment response
