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The estimated loss of skeletal muscle in these two major trials (10% or more during 6872 weeks of treatment) approximates the average decline in muscle mass during 20 years of agingrelated muscle loss in adults older than 30 years, estimated at 3%5% per decade (Figure 5)

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GLP-1R expression and activation were investigated in tanycytes by determining phosphorylation of the cyclic AMP response element binding protein (p-CREB) (Supplemental Figure 3)