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The SELECT trial showed that semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% in people with overweight or obesity and established cardiovascular disease, and benefits appeared early, before substantial weight loss had occurred

It should be noted that only liraglutide currently has an indication for weight loss (at a higher dose of 3 mg once daily) (31)

Among those who lost twenty percent or more of baseline weight on semaglutide, the steepest regain following stopping occurs one year following withdrawal, and many regained about two-thirds of lost weight

Tirzepatide works by activating both the GLP-1 and GIP receptors in your body

GLP-1 medications offer effective tools when combined with proper thyroid hormone replacement and lifestyle modifications